01 - Whisk buttermilk with salt, garlic powder, onion powder, cayenne, and black pepper in a large bowl. Submerge chicken pieces completely. Cover and refrigerate minimum 2 hours, preferably overnight for maximum flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne, and baking powder in a separate bowl. Whisk thoroughly to distribute spices evenly.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, ensuring thick, even coating. Set on wire rack and rest 10 minutes to set coating.
04 - Pour vegetable oil into deep fryer or heavy-bottomed pot. Heat to 350°F, maintaining temperature throughout cooking.
05 - Lower chicken pieces into hot oil in batches, avoiding overcrowding. Fry 12-15 minutes, turning occasionally, until deep golden brown and crisp. Internal temperature must reach 165°F.
06 - Transfer to wire rack or paper towels to drain. Let rest 5 minutes before serving to allow juices to redistribute.